Journal article

Depletion of nitric oxide synthase-containing neurons in the diabetic retina: reversal by aminoguanidine

E Roufail, T Soulis, E Boel, ME Cooper, S Rees

Diabetologia | SPRINGER VERLAG | Published : 1998


A close association of neuronal nitric oxide synthase-immunoreactive (nNOS-IR) neurons with the retinal vasculature has been reported and it is proposed that activation of these neurons could be the mechanism by which retinal blood flow and metabolism are linked. Further, advanced glycation end products (AGEs) have previously been shown to be increased in the diabetic retina and aminoguanidine (AG), an inhibitor of advanced glycation, has been shown to attenuate the development of AGE accumulation as well as the progression of experimental diabetic retinopathy. This study examined the effects of short (1 and 3 weeks) and long term (32 weeks) diabetes on nNOS-containing neurons of the retina ..

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University of Melbourne Researchers