Altered decorin leads to disrupted endothelial cell function: A possible mechanism in the pathogenesis of fetal growth restriction?
A Chui, P Murthi, T Gunatillake, SP Brennecke, V Ignjatovic, PT Monagle, JM Whitelock, JM Said
Placenta | W B SAUNDERS CO LTD | Published : 2014
OBJECTIVE: Fetal growth restriction (FGR) is a key cause of adverse pregnancy outcome where maternal and fetal factors are identified as contributing to this condition. Idiopathic FGR is associated with altered vascular endothelial cell functions. Decorin (DCN) has important roles in the regulation of endothelial cell functions in vascular environments. DCN expression is reduced in FGR. The objectives were to determine the functional consequences of reduced DCN in a human microvascular endothelial cell line model (HMVEC), and to determine downstream targets of DCN and their expression in primary placental microvascular endothelial cells (PLECs) from control and FGR-affected placentae. APPROA..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC), Australia
Sources of funding: This work was supported by National Health and Medical Research Council (NH&MRC) Project Grants (1004952 and 1042239), Australia.