Journal article

Diverse roles of non-diverse molecules: MHC class Ib molecules in host defense and control of autoimmunity

Amelia R Hofstetter, Lucy C Sullivan, Aron E Lukacher, Andrew G Brooks

Current Opinion in Immunology | CURRENT BIOLOGY LTD | Published : 2011


While the prime function of classical MHC class I molecules (MHC-I) is to present peptide antigens to pathogen-specific cytotoxic T cells, non-classical MHC-I antigens perform a diverse array of functions in both innate and adaptive immunity. In this review we summarize recent evidence that non classical MHC-I molecules are not only recognized by pathogen-specific T cells but that they also serve as immunoregulatory molecules by stimulating a number of distinct non-conventional T cell subsets.


Awarded by NIH


Funding Acknowledgements

This work was supported by NIH grants R01 CA139220 and R01 CA71971 (AEL), and by the National Health and Medical Research Council (NHMRC). LCS is supported by a NHMRC Career Development Award.