Rapid systemic and local treatments with the antibacterial peptide dimer A3-APO and its monomeric metabolite eliminate bacteria and reduce inflammation in intradermal lesions infected with Propionibacterium acnes and meticillin-resistant Staphylococcus aureus
Eszter Ostorhazi, Elvira Voros, Eva Nemes-Nikodem, Dora Pinter, Palma Sillo, Balazs Mayer, John D Wade, Laszlo Otvos
International Journal of Antimicrobial Agents | ELSEVIER SCIENCE BV | Published : 2013
When administered intramuscularly, the designer antibacterial peptide dimer A3-APO is highly efficacious in mouse models of Acinetobacter baumannii and Staphylococcus aureus burn infections. Here we compared the efficacy of A3-APO and its monomeric metabolite in mouse models of S. aureus and Propionibacterium acnes intradermal infections following administration as intramuscular (i.m.) or topical treatments. In the animal models, either (i) the ears of CD-1 mice were infected with P. acnes or (ii) S. aureus was injected into burn wounds inflicted to the back. A3-APO or the monomer were injected intramuscularly at 5 mg/kg one to three times or were applied three times as 1% local treatment in..View full abstract
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Awarded by Australian Research Council
Funding: Part of this work was supported by Australian Research Council Discovery grant DP120101963 to JDW, who is also a National Health and Medical Research Council (Australia) Principal Research Fellow. Research at the Florey Institute of Neuroscience and Mental Health (University of Melbourne, Melbourne, Australia) is supported by the Victorian Government Operational Infrastructure Support Program.