Killer Bee Molecules: Antimicrobial Peptides as Effector Molecules to Target Sporogonic Stages of Plasmodium
Victoria Carter, Ann Underhill, Ibrahima Baber, Lakamy Sylla, Mounirou Baby, Isabelle Larget-Thiery, Agnes Zettor, Catherine Bourgouin, Ulo Langel, Ingrid Faye, Laszlo Otvos, John D Wade, Mamadou B Coulibaly, Sekou F Traore, Frederic Tripet, Paul Eggleston, Hilary Hurd
PLoS Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2013
A new generation of strategies is evolving that aim to block malaria transmission by employing genetically modified vectors or mosquito pathogens or symbionts that express anti-parasite molecules. Whilst transgenic technologies have advanced rapidly, there is still a paucity of effector molecules with potent anti-malaria activity whose expression does not cause detrimental effects on mosquito fitness. Our objective was to examine a wide range of antimicrobial peptides (AMPs) for their toxic effects on Plasmodium and anopheline mosquitoes. Specifically targeting early sporogonic stages, we initially screened AMPs for toxicity against a mosquito cell line and P. berghei ookinetes. Promising ca..View full abstract
Awarded by Wellcome Trust
This work was supported by Wellcome Trust Programme Grant 084582, awarded to PE, HH, and FT. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.