Journal article

Community-associated methicillin-resistant Staphylococcus aureus transmission in households of infected cases: a pooled analysis of primary data from three studies across international settings

J Knox, M Van Rijen, A-C Uhlemann, M Miller, C Hafer, P Vavagiakis, Q Shi, PDR Johnson, G Coombs, M Kluytmans-Van den Bergh, J Kluytmans, CM Bennett, FD Lowy

EPIDEMIOLOGY AND INFECTION | CAMBRIDGE UNIV PRESS | Published : 2015

Abstract

Diverse strain types of methicillin-resistant Staphylococcus aureus (MRSA) cause infections in community settings worldwide. To examine heterogeneity of spread within households and to identify common risk factors for household transmission across settings, primary data from studies conducted in New York (USA), Breda (The Netherlands), and Melbourne (Australia) were pooled. Following MRSA infection of the index patient, household members completed questionnaires and provided nasal swabs. Swabs positive for S. aureus were genotyped by spa sequencing. Poisson regression with robust error variance was used to estimate prevalence odds ratios for transmission of the clinical isolate to non-index ..

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