The role of endosomes in innate and adaptive immunity
Paul A Gleeson
Seminars in Cell and Developmental Biology | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2014
The regulation of the immune system is critical for the generation of effective immune responses to a range of pathogens, as well as for protection against unwanted responses. The regulation of many immune response pathways are directly dependent on the organisation and activities of intracellular endosomal compartments associated with cargo sorting, membrane trafficking and signalling. Over the last 5-10 years, the appreciation of the important contribution of the endosomal system has expanded dramatically to include antigen presentation of MHC class I, MHC class II and CD1 molecules, as well as the regulation of antigen receptor signalling and pattern recognition receptor signalling of the..View full abstract
I thank Jose Villadangos and Justine Mintern for helpful discussions and Khalisah Zulkefli for comments on the manuscript. This work was supported by funding from the National Health and Medical Research Council of Australia.