Tissue-resident T cells, in situ immunity and transplantation
Damian L Turner, Claire L Gordon, Donna L Farber
Immunological Reviews | WILEY | Published : 2014
T cells coordinate rejection of transplanted allografts and are key targets for depletion, immunosuppression, and tolerance induction to promote long-term graft survival. Studies in mouse models and humans generally focus on circulating T cells or those from lymphoid sites; however, vast numbers of T cells reside in multiple peripheral tissue sites including lungs, intestines, liver, and skin as non-circulating, tissue-resident memory T cells (Trm cells). In this review, we define the basic properties of Trm cells, the emerging evidence of their importance for protective immunity, and the potential role of resident versus circulating T cells in transplant rejection and in providing protectio..View full abstract
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
This work is supported by AI100119, AI083022, and AI106697 awarded to D. L. F. D. L. T. is supported by a Parker Francis Foundation postdoctoral fellowship. C. G. is supported by a Fullbright Scholarship and Hutchins Family fellowship. The authors have no conflicts of interest to declare.