Journal article
Pancreatic cancer risk and levels of trace elements
AFS Amaral, M Porta, DT Silverman, RL Milne, M Kogevinas, N Rothman, KP Cantor, BP Jackson, JA Pumarega, T López, A Carrato, L Guarner, FX Real, N Malats
Gut | BMJ PUBLISHING GROUP | Published : 2012
Abstract
Background and Aims: Knowledge on the aetiology of exocrine pancreatic cancer (EPC) is scant. The best established risk factor for EPC is tobacco smoking. Among other carcinogens, tobacco contains cadmium, a metal previously associated with an increased risk of EPC. This study evaluated the association between concentrations of trace elements in toenails and EPC risk. Methods: The study included 118 EPC cases and 399 hospital controls from eastern Spain. Levels of 12 trace elements were determined in toenail samples by inductively coupled plasma mass spectrometry. OR and 95% CI, adjusted for potential confounders, were calculated using logistic regression. Results: Significantly increased ri..
View full abstractGrants
Awarded by National Cancer Institute
Funding Acknowledgements
This work was partly supported by the Association for International Cancer Research (AICR09-0780), Fondo de Investigacion Sanitaria, Spain (# PI09-02102), Red Tematica de Investigacion Cooperativa en Cancer (RTICC) and CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Ministry of Health, Spain, Fundacion Cientifica de la Asociacion Espanola Contra el Cancer (AECC) and the Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute, USA. The Dartmouth Trace Element Core is partly supported by NIH grant number P42 ES007373 from the National Institute of Environmental Health Sciences.