The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors

I Landa; S Ruiz-Llorente; C Montero-Conde; L Inglada-Pérez; F Schiavi; S Leskelä; G Pita; R Milne; J Maravall; I Ramos; V Andía; P Rodríguez-Poyo; A Jara-Albarrán; A Meoro; C Del Peso; L Arribas; P Iglesias; J Caballero; J Serrano; A Picó; F Pomares; G Giménez; P López-Mondéjar; R Castello; I Merante-Boschin; MR Pelizzo; D Mauricio; G Opocher; C Rodríguez-Antona; A González-Neira; X Matías-Guiu; P Santisteban; M Robledo

Journal article

The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors

I Landa, S Ruiz-Llorente, C Montero-Conde, L Inglada-Pérez, F Schiavi, S Leskelä, G Pita, R Milne, J Maravall, I Ramos, V Andía, P Rodríguez-Poyo, A Jara-Albarrán, A Meoro, C Del Peso, L Arribas, P Iglesias, J Caballero, J Serrano, A Picó Show all

Plos Genetics | PUBLIC LIBRARY SCIENCE | Published : 2009

DOI: 10.1371/journal.pgen.1000637

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Abstract

In order to identify genetic factors related to thyroid cancer susceptibility, we adopted a candidate gene approach. We studied tag- and putative functional SNPs in genes involved in thyroid cell differentiation and proliferation, and in genes found to be differentially expressed in thyroid carcinoma. A total of 768 SNPs in 97 genes were genotyped in a Spanish series of 615 cases and 525 controls, the former comprising the largest collection of patients with this pathology froma single population studied to date. SNPs in an LD block spanning the entire FOXE1 gene showed the strongest evidence of association with papillary thyroid carcinoma susceptibility. This association was validated in a ..

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University of Melbourne Researchers

Roger Milne Author

Grants

Awarded by Spanish Ministry of Science and Innovation

Awarded by ISCIII Centre for Biomedical Research on Rare Diseases-CIBERER

Awarded by RTICC

Awarded by FIS

Awarded by FPU

Funding Acknowledgements

This work was supported by Grants to MR (Fondo de Investigaciones Sanitarias-FIS project PI080883, by the Spanish Ministry of Science and Innovation; project INTRA-706-2 ISCIII Centre for Biomedical Research on Rare Diseases-CIBERER; and by Fundacion Mutua Madrilena), and to PS (grants from the Spanish Ministry of Science and Innovation: SAF2007-60614, RD06/0020/0060 and Accion Transversal del Cancer-ISCIII-FIS). XMG is partially supported by RTICC (RD06/0020/1034). IL and SL are predoctoral fellows of FIS (FI07/00326) and FPU (AP2005-4514). SRL has an FIS postdoctoral contract (CD05/00055). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.