Journal article

Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: A two-stage Spanish case-control study

Ana Vega, Antonio Salas, Roger L Milne, Begona Carracedo, Gloria Ribas, Alvaro Ruibal, Antonio Cabrera de Leon, Ana Gonzalez-Hernandez, Javier Benitez, Angel Carracedo



OBJECTIVES: A polygenic model has been proposed in order to explain the genetic susceptibility to sporadic breast cancer. According to this model, common population variants would be responsible for low to modest effects on the risk of developing the disease. We have carried out a high-throughput SNP genotyping project in order to shed some light on the complex genetic aetiology of non-familial breast cancer. METHODS: Ninety-one genes have been selected because of their implications in several candidate cell pathways for breast cancer. A total of 640 SNPs in these genes were genotyped in a series of 450 consecutive cases and 448 controls from mainland Spain. Promising SNPs were then studied ..

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Awarded by Xunta de Galicia

Awarded by Spanish Ministerio de Sanidad y Consinno

Funding Acknowledgements

Thanks to Pilar Zaragoza and Jos& Ignacio Arias for providing part of the samples. This work was supported by grants from the Xunta de Galicia, PGIDIT06PXIB208079PR and PGIDIT06BTF910101PR, given to AS and AV respectively, two grants frorn the Fundacion de Investigacion Medica Mutua Madrilefia awarded to AS and AV, and two grants frorn the Spanish Ministerio de Sanidad y Consinno, P1052275 and P1061712, given to AV. and AG. respectively. Genonia Espaha also supported the present study.