Journal article

Phenotypic characterization of an alpha(4) neuronal nicotinic acetylcholine receptor subunit knock-out mouse

SA Ross, JYF Wong, JJ Clifford, A Kinsella, JS Massalas, MK Horne, IE Scheffer, I Kola, JL Waddington, SF Berkovic, J Drago

Journal of Neuroscience | SOC NEUROSCIENCE | Published : 2000

Abstract

Neuronal nicotinic acetylcholine receptors (nAChR) are present in high abundance in the nervous system (Decker et al., 1995). There are a large number of subunits expressed in the brain that combine to form multimeric functional receptors. We have generated an alpha(4) nAChR subunit knock-out line and focus on defining the behavioral role of this receptor subunit. Homozygous mutant mice (Mt) are normal in size, fertility, and home-cage behavior. Spontaneous unconditioned motor behavior revealed an ethogram characterized by significant increases in several topographies of exploratory behavior in Mt relative to wild-type mice (Wt) over the course of habituation to a novel environment. Furtherm..

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