Journal article

Exploring the Modulation of Hypoxia-Inducible Factor (HIF)-1 alpha by Volatile Anesthetics as a Possible Mechanism Underlying Volatile Anesthetic-Induced CNS Injury

Emma K Giles, Andrew J Lawrence, Jhodie R Duncan



This review summarizes recent research on the potential cognitive and behavioural abnormalities induced by exposure to volatile anesthetics and suggests a role of hypoxia-inducible factor (HIF)-1α in mediating these events. Volatile anesthetics are widely utilized in clinical and research settings, yet the long-term safety of exposure to these agents is under debate. Findings from various animal models suggest volatile anesthetics induce widespread apoptosis in the central nervous system (CNS) that correlates with lasting deficits in learning and memory. Longitudinal analysis of clinical data highlight an increased risk of developmental disorders later in life when children are exposed to vo..

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Funding Acknowledgements

These studies were supported by the National Health and Medical Research Council of Australia of which Andrew John Lawrence is a Principal Research Fellow and the Australian Research Council of which Jhodie Rubina Duncan is a Future Fellow. Financial support from the Victorian Government's Operational Infrastructure Support Program is also acknowledged.