Journal article
Brucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats
Yu-ling Li, Qing Liu, Qi Gong, Jun-xu Li, Shou-peng Wei, Yan-ting Wang, Hui Liang, Min Zhang, Li Jing, Zheng Yong, Andrew J Lawrence, Jian-hui Liang
Acta Pharmacologica Sinica | ACTA PHARMACOLOGICA SINICA | Published : 2014
DOI: 10.1038/aps.2014.28
Abstract
AIM: Brucine (BRU) extracted from the seeds of Strychnos nux-vomica L is glycine receptor antagonist. We hypothesize that BRU may modify alcohol consumption by acting at glycine receptors, and evaluated the pharmacodynamic profiles and adverse effects of BRU in rat models of alcohol abuse. METHODS: Alcohol-preferring Fawn-Hooded (FH/Wjd) rats were administered BRU (10, 20 or 30 mg/kg, sc). The effects of BRU on alcohol consumption were examined in ethanol 2-bottle-choice drinking paradigm, ethanol/sucrose operant self-administration paradigm and 5-d ethanol deprivation test. In addition, open field test was used to assess the general locomotor activity of FH/Wjd rats, and conditioned place p..
View full abstractGrants
Awarded by National Natural Science Foundation of China
Awarded by National Basic Research Program of China
Awarded by National Key Technology R&D Program of China
Awarded by Key Research Items of Ministry of Public Security
Awarded by National Institute on Drug Abuse at the National Institutes of Health
Awarded by NATIONAL INSTITUTE ON DRUG ABUSE
Funding Acknowledgements
This study was supported by the National Natural Science Foundation of China (30870894 and 81373390); National Basic Research Program of China (2009CB522000); National Key Technology R&D Program of China (2011BAK04B08); and Key Research Items of Ministry of Public Security (2009ZDYJHLJT003). Jian-hui LIANG was supported by the National Institute on Drug Abuse at the National Institutes of Health under awards (R01DA034806 and R21DA033426). Andrew J LAWRENCE is a Principal Research Fellow at the NHMRC, Australia, and was supported by the Victorian Government's Operational Infrastructure Support Scheme.