Journal article

Brucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats

Yu-ling Li, Qing Liu, Qi Gong, Jun-xu Li, Shou-peng Wei, Yan-ting Wang, Hui Liang, Min Zhang, Li Jing, Zheng Yong, Andrew J Lawrence, Jian-hui Liang

Acta Pharmacologica Sinica | ACTA PHARMACOLOGICA SINICA | Published : 2014

Abstract

AIM: Brucine (BRU) extracted from the seeds of Strychnos nux-vomica L is glycine receptor antagonist. We hypothesize that BRU may modify alcohol consumption by acting at glycine receptors, and evaluated the pharmacodynamic profiles and adverse effects of BRU in rat models of alcohol abuse. METHODS: Alcohol-preferring Fawn-Hooded (FH/Wjd) rats were administered BRU (10, 20 or 30 mg/kg, sc). The effects of BRU on alcohol consumption were examined in ethanol 2-bottle-choice drinking paradigm, ethanol/sucrose operant self-administration paradigm and 5-d ethanol deprivation test. In addition, open field test was used to assess the general locomotor activity of FH/Wjd rats, and conditioned place p..

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Grants

Awarded by National Natural Science Foundation of China


Awarded by National Basic Research Program of China


Awarded by National Key Technology R&D Program of China


Awarded by Key Research Items of Ministry of Public Security


Awarded by National Institute on Drug Abuse at the National Institutes of Health


Awarded by NATIONAL INSTITUTE ON DRUG ABUSE


Funding Acknowledgements

This study was supported by the National Natural Science Foundation of China (30870894 and 81373390); National Basic Research Program of China (2009CB522000); National Key Technology R&D Program of China (2011BAK04B08); and Key Research Items of Ministry of Public Security (2009ZDYJHLJT003). Jian-hui LIANG was supported by the National Institute on Drug Abuse at the National Institutes of Health under awards (R01DA034806 and R21DA033426). Andrew J LAWRENCE is a Principal Research Fellow at the NHMRC, Australia, and was supported by the Victorian Government's Operational Infrastructure Support Scheme.