Journal article

Effect of the histone deacetylase inhibitors on behavioural sensitization to a single morphine exposure in mice

Li Jing, Juan Luo, Min Zhang, Wang-Jun Qin, Yu-Ling Li, Qing Liu, Yan-Ting Wang, Andrew J Lawrence, Jian-Hui Liang

Neuroscience Letters | ELSEVIER IRELAND LTD | Published : 2011

Abstract

Behavioural sensitization to a single morphine exposure has been considered to be a long-term form of behavioural plasticity associated with opioid addiction. Accumulated evidence has shown that histone modification plays a key role in behavioural plasticity. Therefore, this study was designed to investigate whether the histone deacetylase inhibitors sodium butyrate (SB) and valproic acid (VPA) could disrupt behavioural sensitization to a single morphine exposure. Mice were pretreated with a single injection of morphine and elicited subsequent behavioural sensitization by a challenge-dosage of morphine after a 7-day drug-free period. At doses that did not affect the locomotor activity, both ..

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Grants

Awarded by National Nature Science Foundation of China


Awarded by National Basic Research Program of China


Awarded by Tianjin Medical University Science Foundation of China


Funding Acknowledgements

This work was supported by grants from National Nature Science Foundation of China (Nos. 30570653 and 30870894), National Basic Research Program of China (Nos. 2003CB515400 and 2009CB522000), 985 Program of China Ministry of Education (State Key Laboratory of Natural and Biomimetic Drugs, Peking University) and Tianjin Medical University Science Foundation of China (No. 2010ky02). A.J.L. is a Senior Fellow supported by the National Health & Medical Research Council (Australia).