Converting cold into pain
Carlos Belmonte, James A Brock, Felix Viana
Experimental Brain Research | SPRINGER | Published : 2009
Cold temperature can evoke a wide spectrum of perceptual sensations that range from freshness to unpleasant cold or overt pain. In mammals, the detection of cold temperature is accomplished by the activation of different subsets of sensory terminals innervating the skin and mucosae. Direct recordings of corneal nerve endings, combined with studies of thermoreceptive neurons in culture, have allowed the characterization of ionic mechanisms involved in cold temperature sensing. In recent years, major progress has also taken place in the identification and operation of thermally gated ion channels, especially of the transient receptor potential (TRP) family. However, it is still uncertain how i..View full abstract
Awarded by Spanish MICINN
Awarded by CONSOLIDER-INGENIO
The authors are grateful to the former and current members of their laboratories for their experimental contributions that support much of the views expressed in this review. We would also like to acknowledge the funding from the Spanish MICINN (projects BFU2007-61855, BFU2008-04425 and CONSOLIDER-INGENIO 2010 CSD2007-0002) and from the Fundacion Marcelino Botin.