Journal article

Inhibition of K-ATP channels in the rat tail artery by neurally released noradrenaline acting on postjunctional alpha(2)-adrenoceptors

Joy H Tan, Amr Al Abed, James A Brock

The Journal of Physiology | BLACKWELL PUBLISHING | Published : 2007


In rat tail artery, activation of postjunctional alpha(2)-adrenoceptors by noradrenaline (NA) released from sympathetic axons produces a slow depolarization (NAD) of the smooth muscle through a decrease in K(+) conductance. In this study we used intracellular recording to investigate whether the K(+) channel involved is the ATP-sensitive K(+) (K(ATP)) channel. Changes in membrane resistance were monitored by measuring the time constant of decay of excitatory junction potentials. The K(ATP) channel blockers, glibenclamide (10 microm) and PNU 37883A (5 microm), depolarized the smooth muscle and increased membrane resistance. Conversely, the K(ATP) channel openers, pinacidil (0.1 and 0.5 microm..

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University of Melbourne Researchers