Journal article

Tail arteries from chronically spinalized rats have potentiated responses to nerve stimulation in vitro

M Yeoh, EM McLachlan, JA Brock

The Journal of Physiology | WILEY | Published : 2004


Patients with severe spinal cord lesions that damage descending autonomic pathways generally have low resting arterial pressure but bladder or colon distension or unheeded injuries may elicit a life-threatening hypertensive episode. Such episodes (known as autonomic dysreflexia) are thought to result from the loss of descending baroreflex inhibition and/or plasticity within the spinal cord. However, it is not clear whether changes in the periphery contribute to the exaggerated reflex vasoconstriction. The effects of spinal transection at T7-8 on nerve- and agonist-evoked contractions of the rat tail artery were investigated in vitro. Isometric contractions of arterial segments were recorded ..

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University of Melbourne Researchers