Journal article
Follistatin Is Induced by Ionizing Radiation and Potentially Predictive of Radiosensitivity in Radiation-Induced Fibrosis Patient Derived Fibroblasts
HB Forrester, A Ivashkevich, MJ McKay, T Leong, DM de Kretser, CN Sprung
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2013
Abstract
Follistatin is a potent regulator of the inflammatory response and binds to and inhibits activin A action. Activin A is a member of the TGFβ protein superfamily which has regulatory roles in the inflammatory response and in the fibrotic process. Fibrosis can occur following cell injury and cell death induced by agents such as ionizing radiation (IR). IR is used to treat cancer and marked fibrotic response is a normal tissue (non-tumour) consequence in a fraction of patients under the current dose regimes. The discovery and development of a therapeutic to abate fibrosis in these radiosensitive patients would be a major advance for cancer radiotherapy. Likewise, prediction of which patients ar..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
This project was supported through National Institute of Health [grant 5U19AI067773-07] and the 2010 round of the priority-driven Collaborative Cancer Research Scheme (grant 1002743) and funded by the Australian Government Department of Health and Ageing with the assistance of Cancer Australia. Also, this work was supported by the Australian National Health and Medical Research Council; and the Australian National Breast Cancer Foundation [grant PG-08-06; http://www.nbcf.org.au/]. Support was also provided by the Victorian Government's Operational Infrastructure Support Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.