Journal article

Destruction of the arrector pili muscle and fat infiltration in androgenic alopecia

N Torkamani, NW Rufaut, L Jones, R Sinclair

British Journal of Dermatology | WILEY-BLACKWELL | Published : 2014

Abstract

BACKGROUND: Androgenic alopecia (AGA) is the most common hair loss condition in men and women. Hair loss is caused by follicle miniaturization, which is largely irreversible beyond a certain degree of follicular regression. In contrast, hair loss in telogen effluvium (TE) is readily reversible. The arrector pili muscle (APM) connects the follicle to the surrounding skin. OBJECTIVES: To compare histopathological features of the APM in AGA and TE. METHODS: Archival blocks of 4-mm scalp punch biopsies from eight patients with AGA and five with TE were obtained. New 4-mm biopsies from five normal cases were used as controls. Serial 7-μm sections were stained with a modified Masson's trichrome st..

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