Journal article

Reproducibility of aortic intima-media thickness in infants using edge-detection software and manual caliper measurements

Kate McCloskey, Anne-Louise Ponsonby, John B Carlin, Kim Jachno, Michael Cheung, Michael R Skilton, Jane Koleff, Peter Vuillermin, David Burgner



BACKGROUND: Aortic intima-media thickness measured by transabdominal ultrasound (aIMT) is an intermediate phenotype of cardiovascular risk. We aimed to (1) investigate the reproducibility of aIMT in a population-derived cohort of infants; (2) establish the distribution of aIMT in early infancy; (3) compare measurement by edge-detection software to that by manual sonographic calipers; and (4) assess the effect of individual and environmental variables on image quality. METHODS: Participants were term infants recruited to a population-derived birth cohort study. Transabdominal ultrasound was performed at six weeks of age by one of two trained operators. Thirty participants had ultrasounds perf..

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Funding Acknowledgements

The Barwon Infant Study is supported by a National Health and Medical Research Council (NHMRC) Project Grant and the Victorian Government's Operational Infrastructure Support Program.KM is supported by Sidney Myer PhD scholarship.ALP and DPB are supported by a NHMRC Senior Research Fellowship and Honorary National Heart Foundation Future Leader Fellowship.The Heart Research Group at the MCRI is supported by Big W and RCH 1000, RCH Foundation.