Reproducibility of aortic intima-media thickness in infants using edge-detection software and manual caliper measurements
Kate McCloskey, Anne-Louise Ponsonby, John B Carlin, Kim Jachno, Michael Cheung, Michael R Skilton, Jane Koleff, Peter Vuillermin, David Burgner
CARDIOVASCULAR ULTRASOUND | BMC | Published : 2014
BACKGROUND: Aortic intima-media thickness measured by transabdominal ultrasound (aIMT) is an intermediate phenotype of cardiovascular risk. We aimed to (1) investigate the reproducibility of aIMT in a population-derived cohort of infants; (2) establish the distribution of aIMT in early infancy; (3) compare measurement by edge-detection software to that by manual sonographic calipers; and (4) assess the effect of individual and environmental variables on image quality. METHODS: Participants were term infants recruited to a population-derived birth cohort study. Transabdominal ultrasound was performed at six weeks of age by one of two trained operators. Thirty participants had ultrasounds perf..View full abstract
The Barwon Infant Study is supported by a National Health and Medical Research Council (NHMRC) Project Grant and the Victorian Government's Operational Infrastructure Support Program.KM is supported by Sidney Myer PhD scholarship.ALP and DPB are supported by a NHMRC Senior Research Fellowship and Honorary National Heart Foundation Future Leader Fellowship.The Heart Research Group at the MCRI is supported by Big W and RCH 1000, RCH Foundation.