Parasite annexins - New molecules with potential for drug and vaccine development
Andreas Hofmann, Asiah Osman, Chiuan Yee Leow, Patrick Driguez, Donald P McManus, Malcolm K Jones
BioEssays | WILEY-BLACKWELL | Published : 2010
In the last few years, annexins have been discovered in several nematodes and other parasites, and distinct differences between the parasite annexins and those of the hosts make them potentially attractive targets for anti-parasite therapeutics. Annexins are ubiquitous proteins found in almost all organisms across all kingdoms.Here, we present an overview of novel annexins from parasitic organisms, and summarize their phylogenetic and biochemical properties, with a view to using them as drug or vaccine targets. Building on structural and biological information that has been accumulated for mammalian and plant annexins, we describe a predicted additional secondary structure element found in m..View full abstract
Research in the laboratory of A.H. is supported by Griffith University, the Rebecca L Cooper Foundation and the James N. Kirby Foundation. M.K.J. and D.P.M. receive funding from the Australian Research Council and National Health and Medical Research Foundation of Australia. We thank Drs Geoff Gobert and Amber Glanfield for assistance with construction of phylogenetic trees.