Journal article

Targeting of the ring exported protein 1 to the Maurer's clefts is mediated by a two-phase process

Matthew WA Dixon, Paula L Hawthorne, Tobias Spielmann, Karen L Anderson, Katharine R Trenholme, Donald L Gardiner

Traffic | WILEY | Published : 2008

Abstract

Early development of Plasmodium falciparum within the erythrocyte is characterized by the large-scale export of proteins to the host cell. In many cases, export is mediated by a short sequence called the Plasmodium export element (PEXEL) or vacuolar transport signal; however, a number of previously characterized exported proteins do not contain such an element. In this study, we investigated the mechanisms of export of the PEXEL-negative ring exported protein 1 (REX1). This protein localizes to the Maurer's clefts, parasite-induced structures in the host-cell cytosol. Transgenic parasites expressing green fluorescent protein-REX1 chimeras revealed that the single hydrophobic stretch plus an ..

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University of Melbourne Researchers