Journal article

Opioids, ventilation and acute pain management

PE Macintyre, JA Loadsman, DA Scott

Anaesthesia and Intensive Care | AUSTRALIAN SOC ANAESTHETISTS | Published : 2011


Despite the increasing use of a variety of different analgesic strategies, opioids continue as the mainstay for management of moderate to severe acute pain. However concerns remain about their potential adverse effects on ventilation. The most commonly used term, respiratory depression, only describes part of that risk. Opioid-induced ventilatory impairment (OIVI) is a more complete term encompassing opioid-induced central respiratory depression (decreased respiratory drive), decreased level of consciousness (sedation) and upper airway obstruction, all of which, alone or in combination, may result in decreased alveolar ventilation and increased arterial carbon dioxide levels. Concerns about ..

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University of Melbourne Researchers