Journal article

Mortality Related to Severe Sepsis and Septic Shock Among Critically III Patients in Australia and New Zealand, 2000-2012

Kirsi-Maija Kaukonen, Michael Bailey, Satoshi Suzuki, David Pilcher, Rinaldo Bellomo

JAMA: Journal of the American Medical Association | AMER MEDICAL ASSOC | Published : 2014


IMPORTANCE: Severe sepsis and septic shock are major causes of mortality in intensive care unit (ICU) patients. It is unknown whether progress has been made in decreasing their mortality rate. OBJECTIVE: To describe changes in mortality for severe sepsis with and without shock in ICU patients. DESIGN, SETTING, AND PARTICIPANTS: Retrospective, observational study from 2000 to 2012 including 101,064 patients with severe sepsis from 171 ICUs with various patient case mix in Australia and New Zealand. MAIN OUTCOMES AND MEASURES: Hospital outcome (mortality and discharge to home, to other hospital, or to rehabilitation). RESULTS: Absolute mortality in severe sepsis decreased from 35.0% (95% CI, 3..

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University of Melbourne Researchers


Funding Acknowledgements

All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Kaukonen reported having received a grant for clinical research career from the Academy of Finland. Dr Bellomo reported having received personal fees and nonfinancial support from Gambro, grants and personal fees from Baxter and personal fees from Philips and Braun. No other disclosures were reported.