A metabolic link to skeletal muscle wasting and regeneration
Rene Koopman, C Hai Ly, James G Ryall
FRONTIERS IN PHYSIOLOGY | FRONTIERS MEDIA SA | Published : 2014
Due to its essential role in movement, insulating the internal organs, generating heat to maintain core body temperature, and acting as a major energy storage depot, any impairment to skeletal muscle structure and function may lead to an increase in both morbidity and mortality. In the context of skeletal muscle, altered metabolism is directly associated with numerous pathologies and disorders, including diabetes, and obesity, while many skeletal muscle pathologies have secondary changes in metabolism, including cancer cachexia, sarcopenia and the muscular dystrophies. Furthermore, the importance of cellular metabolism in the regulation of skeletal muscle stem cells is beginning to receive s..View full abstract
James G. Ryall is supported by an Overseas Biomedical Research Fellowship from the National Health and Medical Research Council of Australia.