Journal article

RYK, A RECEPTOR TYROSINE KINASE-RELATED MOLECULE WITH UNUSUAL KINASE DOMAIN MOTIFS

CM HOVENS, SA STACKER, AC ANDRES, AG HARPUR, A ZIEMIECKI, AF WILKS

Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 1992

Abstract

By using the polymerase chain reaction with degenerate oligonucleotides based on highly conserved motifs held in common between all members of the protein tyrosine kinase (PTK) family, a PTK-related sequence was isolated from murine peritoneal macrophage cDNA. Full-length clones have been isolated that encompass the entire coding region of the mRNA, and the predicted amino acid sequence indicates that the protein encoded has the structure of a growth factor receptor PTK (RTK). We have dubbed this molecule RYK (for related to tyrosine kinase). The RYK-encoded protein bears a transmembrane domain, with a relatively small (183 amino acid) extracellular domain, containing five potential N-linked..

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