Transforming growth factor beta family expression at the bovine feto-maternal interface
Kumiko Sugawara, Keiichiro Kizaki, Chandana B Herath, Yoshihisa Hasegawa, Kazuyoshi Hashizume
Reproductive Biology and Endocrinology | BMC | Published : 2010
BACKGROUND: Endometrial remodelling is necessary for implantation in all mammalian species. The TGF beta super-family plays a crucial role in this event in humans and mice. However, the role of TGF beta super-family members during implantation is still unclear in ruminants. In the present study, the spacio-temporal expression of TGF beta super-family members including activin was explored in bovine trophoblasts and endometrial tissue during the peri-implantation period in order to elucidate whether it is essential for promoting cell proliferation at the implantation site. METHODS: Gene expression in the fetal membrane and endometrium of the gravid and non-gravid horn around Day 35 of gestati..View full abstract
Awarded by Ministry of Agriculture, Forestry, and Fisheries of Japan
Awarded by Ministry of Education, Culture, Sport, Science, and Technology of Japan
This research was supported by a grant from the Research Project for Utilizing Advanced Technologies (05-1770) from the Ministry of Agriculture, Forestry, and Fisheries of Japan and grants (Kiban-kenkyu C 17580284; Kiban-kenkyu B 20380159) from the Ministry of Education, Culture, Sport, Science, and Technology of Japan. We thank Dr. Nobuhiko Yamauchi, Kyushu University for supply information of bovine endometrial and cotyledonary fibroblast cells. We thank Drs. Toru Takahashi, Misa Hosoe and Koichi Ushizawa for help to collect samples and performed microarray.