Journal article

Adverse effects of environmental toxicants, octylphenol and bisphenol A, on male reproductive functions in pubertal rats

CB Herath, WZ Jin, G Watanabe, K Arai, AK Suzuki, K Taya

Endocrine | SPRINGER | Published : 2004


It has been proposed that a global decline in sperm counts, semen quality, and several male reproductive disorders are associated with exposure to environmental chemicals. Thus, the present study examined the effects of two estrogenic chemicals, octylphenol (OP) and bisphenol A (BPA), on epididymal sperm counts and sperm motility, luteinizing hormone (LH)-releasing hormone (LHRH)-stimulated plasma LH and steroid hormones, insulin-like growth factor I (IGF-I), and accessory reproductive organs in pubertal male Wistar rats. Fifty-day-old rats in the OP group (n=11) and BPA group (n=11) received daily sc injections of the respective chemical at a dose of 3 mg/kg bw dissolved in 0.2 mL DMSO. Rat..

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University of Melbourne Researchers