Mechanisms and regulation of endometrial angiogenesis

Abstract

In conclusion, as a tissue that undergoes constant and major remodelling, and is involved in several blood-vessel-related pathologies, human endometrium is an ideal albeit complex model for the study of angiogenesis. This complexity is evident from the large number of angiogenic growth factors found in endometrium, many of whose expression patterns do not seem to correlate with known angiogenic events. Further fundamental studies are required to elucidate the key mechanisms that regulate endometrial angiogenesis. A better understanding these mechanisms will be key in developing applications for emerging antiangiogenic medical agents in the treatment of diseases such as endometriosis and endo..