Journal article

Subjective memory complaints with and without objective memory impairment - Relationship with risk factors for dementia

NT Lautenschlager, L Flicker, S Vasikaran, P Leedman, OP Almeida

American Journal of Geriatric Psychiatry | ELSEVIER SCIENCE INC | Published : 2005

Abstract

OBJECTIVE: The authors investigated the frequency distribution of well-established risk factors for dementia--high plasma homocysteine and the apolipoprotein E epsilon4 allele (APOE epsilon4)--among older women with subjective memory complaints (SMC) but no cognitive impairment, and with mild cognitive impairment (MCI). METHODS: This was a cross-sectional, community-based study. RESULTS: Women with MCI had higher total plasma homocysteine than healthy-comparison subjects. There was also a nonsignificant excess of APOE epsilon4 carriers in the MCI than in the healthy group. Participants with SMC had higher depression and anxiety scores than healthy-comparison subjects, but did not differ from..

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