Navigating the future of bacterial molecular epidemiology
Stephen Baker, William P Hanage, Kathryn E Holt
Current opinion in microbiology | CURRENT BIOLOGY LTD | Published : 2010
Technological advances in high-throughput genome sequencing have led to an enhanced appreciation of the genetic diversity found within populations of pathogenic bacteria. Methods based on single nucleotide polymorphisms (SNPs) and insertions or deletions (indels) build upon the framework established by multi-locus sequence typing (MLST) and permit a detailed, targeted analysis of variation within related organisms. Robust phylogenetics, when combined with epidemiologically informative data, can be applied to study ongoing temporal and geographical fluctuations in bacterial pathogens. As genome sequencing, SNP detection and geospatial information become more accessible these methods will cont..View full abstract
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Awarded by NHMRC of Australia
This work was supported by The Wellcome Trust, Euston Road, London, United Kingdom. SB is supported by an OAK foundation fellowship through Oxford University. KEH is supported by a Fellowship from the NHMRC of Australia (628930).