Typhoid in Kenya Is Associated with a Dominant Multidrug-Resistant Salmonella enterica Serovar Typhi Haplotype That Is Also Widespread in Southeast Asia
Samuel Kariuki, Gunturu Revathi, John Kiiru, Doris M Mengo, Joyce Mwituria, Jane Muyodi, Agnes Munyalo, Yik Y Teo, Kathryn E Holt, Robert A Kingsley, Gordon Dougan
Journal of clinical microbiology | AMER SOC MICROBIOLOGY | Published : 2010
In sub-Saharan Africa, the burden of typhoid fever, caused by Salmonella enterica serovar Typhi, remains largely unknown, in part because of a lack of blood or bone marrow culture facilities. We characterized a total of 323 S. Typhi isolates from outbreaks in Kenya over the period 1988 to 2008 for antimicrobial susceptibilities and phylogenetic relationships using single-nucleotide polymorphism (SNP) analysis. There was a dramatic increase in the number and percentage of multidrug-resistant (MDR) S. Typhi isolates over the study period. Overall, only 54 (16.7%) S. Typhi isolates were fully sensitive, while the majority, 195 (60.4%), were multiply resistant to most commonly available drugs-am..View full abstract
Awarded by Wellcome Trust
The work was supported by Wellcome Trust Grant no. 064616/01/Z.