Environmental, Personal, and Genetic Determinants of Response to Vitamin D Supplementation in Older Adults
Mary Waterhouse, Bich Tran, Bruce K Armstrong, Catherine Baxter, Peter R Ebeling, Dallas R English, Val Gebski, Christine Hill, Michael G Kimlin, Robyn M Lucas, Alison Venn, Penelope M Webb, David C Whiteman, Rachel E Neale
Journal of Clinical Endocrinology & Metabolism | ENDOCRINE SOC | Published : 2014
CONTEXT AND OBJECTIVE: Suboptimal vitamin D status can be corrected by vitamin D supplementation, but individual responses to supplementation vary. We aimed to examine genetic and nongenetic determinants of change in serum 25-hydroxyvitamin D (25(OH)D) after supplementation. DESIGN AND PARTICIPANTS: We used data from a pilot randomized controlled trial in which 644 adults aged 60 to 84 years were randomly assigned to monthly doses of placebo, 30 000 IU, or 60 000 IU vitamin D3 for 12 months. Baseline characteristics were obtained from a self-administered questionnaire. Eighty-eight single-nucleotide polymorphisms (SNPs) in 41 candidate genes were genotyped using Sequenom MassArray technology..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) of Australia
This project was funded by the National Health and Medical Research Council (NHMRC) of Australia (Grant 613655). The investigational product was supplied free of charge by Sanofi-Aventis Healthcare Pty Ltd trading as Sanofi Consumer Healthcare. P.M.W., R.E.N., and A.V. are supported by Fellowships from the NHMRC. D.C.W. is supported by a Future Fellowship from the Australian Research Council. R.M.L. is supported by an NHMRC Career Development Fellowship. M.G.K. is supported through a Cancer Council Queensland Senior Research Fellowship.