Adenosine Triphosphate-Induced Photoreceptor Death and Retinal Remodeling In Rats
Kirstan A Vessey, Ursula Greferath, Felix P Aplin, Andrew I Jobling, Joanna A Phipps, Tracy Ho, Robbert U De Iongh, Erica L Fletcher
JOURNAL OF COMPARATIVE NEUROLOGY | WILEY | Published : 2014
Many common causes of blindness involve the death of retinal photoreceptors, followed by progressive inner retinal cell remodeling. For an inducible model of retinal degeneration to be useful, it must recapitulate these changes. Intravitreal administration of adenosine triphosphate (ATP) has recently been found to induce acute photoreceptor death. The aim of this study was to characterize the chronic effects of ATP on retinal integrity. Five-week-old, dark agouti rats were administered 50 mM ATP into the vitreous of one eye and saline into the other. Vision was assessed using the electroretinogram and optokinetic response and retinal morphology investigated via histology. ATP caused signific..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Grant sponsor: Australian Research Council (ARC) Special Research Initiative (SRI) in Bionic Vision Science and Technology (to Bionic Vision Australia); Grant sponsor: National Health and Medical Research Council of Australia; Grant number: 1021042.