Journal article
Physiological mechanisms of upper airway hypotonia during REM sleep
DG McSharry, JP Saboisky, P DeYoung, AS Jordan, J Trinder, E Smales, L Hess, NL Chamberlin, A Malhotra
Sleep | Published : 2014
DOI: 10.5665/sleep.3498
Abstract
Study Objectives: Rapid eye movement (REM)-induced hypotonia of the major upper airway dilating muscle (genioglossus) potentially contributes to the worsening of obstructive sleep apnea that occurs during this stage. No prior human single motor unit (SMU) study of genioglossus has examined this possibility to our knowledge. We hypothesized that genioglossus SMUs would reduce their activity during stable breathing in both tonic and phasic REM compared to stage N2 sleep. Further, we hypothesized that hypopneas occurring in REM would be associated with coincident reductions in genioglossus SMU activity. Design: The activity of genioglossus SMUs was studied in (1) neighboring epochs of stage N2,..
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Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
This was not an industry supported study. The following grants provided support for this study: Dr. Malhotra is PI on AHA 0840159N, NIH R01 HL090897, NIH K24 HL 093218, NIH 1 P01 HL 095491 (Overall PI: Saper, Brigham PI: Malhotra), NIH R01HL110350, NIH UM1HL108724 (Overall PIs: Talmor/Loring, Brigham PI: Malhotra), NIH R01-AG035117, NIH R01 HL085188. The Harvard Catalyst is funded by UL1 RR 025758-01. David McSharry was PI on AHA 11POST5660004. Dr. Malhotra has received consulting and/or research income from Philips Respironics, Pfizer, SHC, SGS, Apnex, Apnicure, but had no personal outside income following May 2012. Dr. Jordan consulted for Apnex Medical from 2009-2010. The other authors have indicated no financial conflicts of interest.