Mitogen activated protein kinase signaling in the kidney: Target for intervention?
MH De Borst, L Wassef, DJ Kelly, H Van Goor, G Navis
Signal Transduction | Published : 2006
Mitogen activated protein kinases (MAPKs) are intracellular signal transduction molecules, which connect cell-surface receptor signals to intracellular processes. MAPKs regulate a range of cellular activities including cell proliferation, gene expression, apoptosis, cell differentiation and cytokine production. The MAPK superfamily consists of at least four families: extracellular signal-regulated kinase (ERK), p38 MAPK, Jun-NH2-terminal kinase (JNK), and ERK5. Each of these families exerts particular downstream effects, although interactions have been described. MAPK activity is present in the normal kidney. Moreover, in various types of renal disease, renal MAPK expression is increased. In..View full abstract