Structural Brain Imaging in Schizophrenia and Related Populations

Abstract

Numerous structural MRI studies have shown that there is a gross neuroanatomy of schizophrenia, which is most evident in the prefrontal cortex and temporal lobe, and detectable to some extent in relatives and other high-risk subjects, although it is of unclear relation to features of the disorder. Proton MRS has also demonstrated NAA reductions in these same regions in patients with schizophrenia and different abnormalities in affective disorder. Methods for DT-MRI studies are evolving rapidly but there are replicated accounts of anatomical disconnectivity in several fronto-temporal and other white matter tracts. The principal challenges now are to identify the time course and causes of thes..