Androgen receptor exon 1 CAG repeat length and breast cancer in women before age forty years

Abstract

Background: We conducted a population-based, case-control-family study to determine whether androgen receptor (AR) exon 1 polymorphic CAG repeat length (CAG(n)) was a risk factor for early-onset breast cancer in the Australian population. Methods: Case subjects under 40 years of age at diagnosis of a first primary breast cancer and age-matched control subjects were interviewed to assess family history and other risk factors. AR CAG(n), length was determined for 368 case subjects and 284 control subjects. Distributions in the two groups were compared by linear and logistic regression, allowing adjustment for measured risk factors. All statistical tests were two-tailed. Results: When analyzed ..