Volumetric analysis of cerebral hypoperfusion on SPECT: Validation and reliability

Abstract

A method of volumetric analysis of hypoperfusion on 99mTc-labeled hexamethylpropylene amine oxime SPECT has been developed. This analysis integrates both the size and severity of perfusion reduction, yielding an equivalent volume of cortical tissue having zero blood flow, or the effective hypoperfusion volume. This study aimed to validate the methodology in vitro using the Hoffman brain phantom and two different camera systems, to examine the relationship between spatial resolution and accuracy of volume measurement and to assess the interobserver variability in SPECT studies of stroke patients. Methods: Simulated cortical lesions of three different sizes were sequentially incorporated into ..