Journal article

LONGITUDINAL ANALYSIS OF LUNG-FUNCTION GROWTH IN HEALTHY-CHILDREN AND ADOLESCENTS

JL HOPPER, ME HIBBERT, GT MACASKILL, PD PHELAN, LI LANDAU

JOURNAL OF APPLIED PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 1991

Abstract

Lung function and height in 242 8-yr-old and 299 12-yr-old children without known or suspected predisposition to lung disease were measured annually over 6 and 8 yr, respectively. Growth of forced expiratory volume in 1 s (FEV1), vital capacity, and expiratory flow after expiring 50% of vital capacity were statistically modeled by age and height by use of a multivariate normal model for longitudinal data. This method has the flexibility to fit an appropriate (not necessarily linear) mathematical description of average lung function while concurrently modeling the covariance between measures on the same individual. Differences in lung function growth between girls and boys, pre- and post-pube..

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