cAMP Response Element Binding Protein Is Required for Differentiation of Respiratory Epithelium during Murine Development
A Daniel Bird, Sharon J Flecknoe, Kheng H Tan, P Fredrik Olsson, Nisha Antony, Theo Mantamadiotis, Stuart B Hooper, Timothy J Cole
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2011
The cAMP response element binding protein 1 (Creb1) transcription factor regulates cellular gene expression in response to elevated levels of intracellular cAMP. Creb1(-/-) fetal mice are phenotypically smaller than wildtype littermates, predominantly die in utero and do not survive after birth due to respiratory failure. We have further investigated the respiratory defect of Creb1(-/-) fetal mice during development. Lungs of Creb1(-/-) fetal mice were pale in colour and smaller than wildtype controls in proportion to their reduced body size. Creb1(-/-) lungs also did not mature morphologically beyond E16.5 with little or no expansion of airway luminal spaces, a phenotype also observed with ..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by a program grant of the National Health and Medical Research Council of Australia (ID no. 384100). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.