Journal article

Long-term differential effects of chronic young-adult corticosterone exposure on anxiety and depression-like behaviour in BDNF heterozygous rats depend on the experimental paradigm used

Anand Gururajana, Rachel Hill, Maarten van den Buuse

Neuroscience Letters | ELSEVIER IRELAND LTD | Published : 2014

Abstract

Brain-derived neurotrophic factor (BDNF) has key roles in neurodevelopment and synaptic plasticity and is implicated in affective disorders such as anxiety and depression. The aim of the present study was to use BDNF heterozygous mutant rats (HET) and wildtype controls (WT) to investigate the effect of BDNF downregulation on affective behaviours. We also assessed the longterm effects of young-adult stress, here simulated by chronic corticosterone (CORT) treatment. This treatment reduced anxiety-like behaviour in BDNF HET rats on the plus-maze but not in the open-field. There were no genotype or CORT effects on immobility time in the forced swim test. These results show differential effects o..

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Grants

Funding Acknowledgements

This work was supported by a National Health and Medical Research Council of Australia (NHMRC) senior research fellowship to MvdB, a NHMRC postdoctoral training fellowship to RH, and a NHMRC project grant. Additional support was obtained by way of operational infrastructure funding from the Victorian State Government. These funding sources had no influence in the study design, the collection, analysis and interpretation of data, the writing of the report, or the decision to submit the article for publication.