High stress hormone levels accelerate the onset of memory deficits in male Huntington's disease mice
Christina Mo, Terence Y Pang, Mark I Ransome, Rachel A Hill, Thibault Renoir, Anthony J Hannan
NEUROBIOLOGY OF DISEASE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2014
Huntington's disease (HD) is a neurodegenerative disorder caused by a tandem repeat mutation in the huntingtin gene. Lifestyle factors, such as lack of activity may contribute to the variability in the age of disease onset. Therefore, better understanding of environmental modifiers may uncover potential therapeutic approaches to delay disease onset and progression. Recent data suggest that HD patients and transgenic mouse models show a dysregulated stress response. In this present study, we elevated stress hormone levels through oral corticosterone (CORT) treatment and assessed its impact on the development of motor impairment and cognitive deficits using the R6/1 transgenic mouse model of H..View full abstract
A.J.H. is an ARC Future Fellow (FT3) and Honorary NHMRC Senior Research Fellow. C.M. is a University of Melbourne Australian Postgraduate Award Scholar. The Florey Institute of Neuroscience and Mental Health acknowledge the support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.