Journal article

Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteristics in the European Prospective Investigation into Cancer and Nutrition

Jennifer Ose, Renee T Fortner, Sabina Rinaldi, Helena Schock, Kim Overvad, Anne Tjonneland, Louise Hansen, Laure Dossus, Agnes Fournier, Laura Baglietto, Isabelle Romieu, Elisabetta Kuhn, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Domenico Palli, Giovanna Masala, Sabina Sieri, Rosario Tumino Show all

International Journal of Cancer | WILEY | Published : 2015

Abstract

The role of endogenous androgens and sex hormone-binding globulin (SHBG) in ovarian carcinogenesis is poorly understood. Epithelial invasive ovarian cancer (EOC) is a heterogeneous disease and there are no prospective data on endogenous androgens and EOC risk by tumor characteristics (histology, grade, stage) or the dualistic model of ovarian carcinogenesis (i.e. type I vs. type II, leading to less or more aggressive tumors). We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort evaluating androgens and SHBG and invasive EOC risk by tumor characteristics. Female participants who provided a blood sample and were not using ex..

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Grants

Awarded by Statistics Netherlands (The Netherlands)


Awarded by Regional Government of Basque Country, Murcia


Awarded by ISCIII RETIC (Spain)


Awarded by Cancer Research UK


Funding Acknowledgements

Grant sponsor: European Commission (DG-SANCO), International Agency for Research on Cancer, Danish Cancer Society (Denmark), Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de l'Education Nationale, Institut National de la Sante et de la Recherche Medicale (INSERM) (France), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany), Hellenic Health Foundation (Greece), Italian Association for Research on Cancer (AIRC) and National Research Council (Italy), Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Grant number: ERC-2009-AdG 232997; Grant sponsors: Nordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health. (Norway), Health Research Fund (FIS), Regional Governments of Andalucia, Asturias, Basque Country, Murcia; Grant number: 6236; Grant sponsors: Navarra and ISCIII RETIC (Spain); Grant number: RD06/0020; Grant sponsors: Swedish Cancer Society, Swedish Scientific Council and Regional Government of Skane and Vasterbotten (Sweden) and Cancer Research UK, Medical Research Council (United Kingdom)