Association between Melanocytic Nevi and Risk of Breast Diseases: The French E3N Prospective Cohort
Marina Kvaskoff, Anne Bijon, Sylvie Mesrine, Alice Vilier, Laura Baglietto, Agnes Fournier, Francoise Clavel-Chapelon, Laure Dossus, Marie-Christine Boutron-Ruault
PLoS Medicine | PUBLIC LIBRARY SCIENCE | Published : 2014
BACKGROUND: While melanocytic nevi have been associated with genetic factors and childhood sun exposure, several observations also suggest a potential hormonal influence on nevi. To test the hypothesis that nevi are associated with breast tumor risk, we explored the relationships between number of nevi and benign and malignant breast disease risk. METHODS AND FINDINGS: We prospectively analyzed data from E3N, a cohort of French women aged 40-65 y at inclusion in 1990. Number of nevi was collected at inclusion. Hazard ratios (HRs) for breast cancer and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression models. Associations of number of nevi with personal ..View full abstract
Awarded by Marie Curie International Outgoing Fellowship within the 7th European Community Framework Programme
This work was supported by the Mutuelle Generale de l'Education Nationale (MGEN); the European Community; the French League against Cancer (LNCC); Gustave Roussy; and the French National Institutes for Health and Medical Research (Inserm). MK is financially supported by a Marie Curie International Outgoing Fellowship within the 7th European Community Framework Programme (#PIOF-GA-2011-302078) (URL: http://ec.europa.eu/research/mariecurieactions/about-mca/actions/iof/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.