Journal article

Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer

Ian PM Tomlinson, Richard S Houlston, Grant W Montgomery, Oliver M Sieber, Malcolm G Dunlop

Mutagenesis | OXFORD UNIV PRESS | Published : 2012

Abstract

Despite their prime candidate status, polymorphisms near genes involved in DNA repair or in other functions related to genome stability have been conspicuously under-represented in the significant associations reported from genome-wide association studies (GWAS) of cancer susceptibility. In this study, we assessed a set of single-nucleotide polymorphisms (SNPs) near 157 DNA repair genes in three colorectal cancer (CRC) GWAS. Although no individual SNP showed evidence of association, the set of SNPs as a whole was associated with colorectal cancer risk. When candidate SNPs were examined, our data did not support most of the previously reported associations with CRC susceptibility, an exceptio..

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University of Melbourne Researchers