Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer
Ian PM Tomlinson, Richard S Houlston, Grant W Montgomery, Oliver M Sieber, Malcolm G Dunlop
Mutagenesis | OXFORD UNIV PRESS | Published : 2012
Despite their prime candidate status, polymorphisms near genes involved in DNA repair or in other functions related to genome stability have been conspicuously under-represented in the significant associations reported from genome-wide association studies (GWAS) of cancer susceptibility. In this study, we assessed a set of single-nucleotide polymorphisms (SNPs) near 157 DNA repair genes in three colorectal cancer (CRC) GWAS. Although no individual SNP showed evidence of association, the set of SNPs as a whole was associated with colorectal cancer risk. When candidate SNPs were examined, our data did not support most of the previously reported associations with CRC susceptibility, an exceptio..View full abstract
Awarded by Cancer Research UK
Awarded by Medical Research Council
This work was supported by Cancer Research UK.