Journal article

Size and Phase Control of Cubic Lyotropic Liquid Crystal Nanoparticles

Terence E Hartnett, Katharina Ladewig, Andrea J O'Connor, Patrick G Hartley, Keith M McLean

Journal of Physical Chemistry B | AMER CHEMICAL SOC | Published : 2014


The effective use of lyotropic liquid crystalline dispersions, such as cubosomes, as drug delivery vehicles requires that they have tailored physical characteristics that suit specific therapeutics and external conditions. Here, we have developed phytantriol-based cubosomes from a dispersion of unilamellar vesicles and show that we can control their size as well as the critical packing parameter (CPP) of the amphiphilic bilayer through regulation of temperature and salt concentration, respectively. Using the anionic biological lipid 1,2-dipalmi-toylphosphatidylserine (DPPS) to prevent the cubic phase from forming, we show that the addition of phosphate buffered saline (PBS) results in a tran..

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University of Melbourne Researchers


Awarded by Australian Research Council (ARC)

Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

T.E. Hartnett would like to thank The University of Melbourne, the Commonwealth Scientific and Industrial Research Organisation (CSIRO), and the Melbourne Materials Institute (MMI) for various scholarships. K. Ladewig acknowledges financial support from the Australian Research Council (ARC) in the form of an ARC Super Science Fellowship (FS 110200025). Infrastructure support from the Particulate Fluids Processing Centre (PFPC), the MMI, CSIRO and The University of Melbourne is gratefully acknowledged. This research was undertaken on the SAXS/WAXS beamline at the Australian Synchrotron, Victoria, Australia (M5720). Cryo-TEM images were obtained with the assistance of Ms. Lynne Waddington, CSIRO, Parkville. Financial support was also provided by the National Health and Medical Research Council (NHMRC, Program Grant 1047603).