Rosetting in Plasmodium vivax : A Cytoadhesion Phenotype Associated with Anaemia
Alejandro Marin-Menendez, Azucena Bardaji, Flor E Martinez-Espinosa, Camila Botto-Menezes, Marcus V Lacerda, Jon Ortiz, Pau Cistero, Mireia Piqueras, Ingrid Felger, Ivo Mueeller, Jaume Ordi, Hernando del Portillo, Clara Menendez, Mats Wahlgren, Alfredo Mayor
PLoS Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2013
BACKGROUND: Plasmodium vivax can potentially lead to life-threatening episodes but the mechanisms underlying severe disease remain poorly defined. Cytoadhesion of infected erythrocytes may contribute to P. vivax sequestration and organ injury although its physiological impact is still unknown. Here, we aimed to describe clinically-relevant cytoadhesive phenotypes of P. vivax isolates. METHODOLOGY/PRINCIPAL FINDINGS: Rosetting and adhesion to CSA, CD36, ICAM1, placental and brain cryosections were determined in P. vivax peripheral isolates from 12 pregnant women, 24 non-pregnant women and 23 men from Manaus (Brazil). P. falciparum co-infection was excluded by PCR and P. vivax isolates were ge..View full abstract
Awarded by European Union
Awarded by Instituto de Salud Carlos III
This work was supported by the European Union's Seventh Framework Programme (FP7-2007-HEALTH) under grant agreement no 201588 and the Malaria in Pregnancy Consortium (MiPc). A. Mayor receives salary support from the Instituto de Salud Carlos III [grant number CP-04/00220]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.