Journal article

Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study

Chloe YY Cheung, Elaine YL Hui, Bernard MY Cheung, YC Woo, Aimin Xu, Carol HY Fong, KL Ong, CY Yeung, Edward D Janus, Hung-Fat Tse, Pak C Sham, Karen SL Lam

European Journal of Endocrinology | BIOSCIENTIFICA LTD | Published : 2014

Abstract

OBJECTIVE: Circulating adiponectin levels have been shown to be associated with a risk of coronary heart disease (CHD). However, its primary role in protecting against the development of CHD remains controversial due to conflicting observations in prospective studies. To gain further insight into the primary role of adiponectin, our major objective was to investigate the relationship between single nucleotide polymorphisms (SNPs) of the adiponectin gene (ADIPOQ) and incident CHD in a population-based cohort with no CHD at baseline. DESIGN AND METHODS: We conducted a 16-year longitudinal study in 2196 subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS). During 33 ..

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University of Melbourne Researchers