Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study
Chloe YY Cheung, Elaine YL Hui, Bernard MY Cheung, YC Woo, Aimin Xu, Carol HY Fong, KL Ong, CY Yeung, Edward D Janus, Hung-Fat Tse, Pak C Sham, Karen SL Lam
European Journal of Endocrinology | BIOSCIENTIFICA LTD | Published : 2014
OBJECTIVE: Circulating adiponectin levels have been shown to be associated with a risk of coronary heart disease (CHD). However, its primary role in protecting against the development of CHD remains controversial due to conflicting observations in prospective studies. To gain further insight into the primary role of adiponectin, our major objective was to investigate the relationship between single nucleotide polymorphisms (SNPs) of the adiponectin gene (ADIPOQ) and incident CHD in a population-based cohort with no CHD at baseline. DESIGN AND METHODS: We conducted a 16-year longitudinal study in 2196 subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS). During 33 ..View full abstract
Awarded by Hong Kong Research Grant Council (RGC)
This work was supported by the Hong Kong Research Grant Council (RGC) Theme-Based Research Scheme (TBRS) Grant T12-705/11.